Treatments

Description of available treatments

IVF/ICSI treatments

PGS/PGD ( Preimplantation Genetic Screening & Preimplantation Genetic Diagnosis )

Preimplantation Genetic Screening

Preimplantation genetic screening (PGS) is a method to detect numerical chromosome abnormalities in the embryo before it is transferred back to the uterus. These abnormalities increase greatly with maternal age, and can be the cause of recurrent miscarriage of repeat IVF failure. Recently, London Fertility Centre has obtained an HFEA (Human Fertilisation and Embryology Authority) licence to perform PGS using Comparative Genomic Hybridisation (CGH). By utilising CGH we are able to screen all 23 pairs of chromosomes within an embryo.

Preimplantation Genetic Diagnosis

Preimplantation genetic diagnosis (PGD) is a method designed for couples who are at risk of transmitting an inherited disease to their children because of chromosomal abnormalities or single gene disorders. Chromosome abnormalities are major category of genetic disease and account for large proportion of reproductive wastage, congenital malformations and mental retardation. Single gene disorders can also be passed from individuals to their offspring, and usually have simple inheritance patterns within a family pedigree according to the category of disease (dominant, recessive or X-linked).

PGD is a method to detect structural chromosome abnormalities and single gene disorders in the embryo before it is transferred back to the uterus. It therefore provides an alternative to prenatal screening, and the difficult decision regarding termination of an affected pregnancy.
London Fertility Centre is licensed by HFEA to perform PGD on all chromosome abnormalities and we are currently expanding our licence to include more single gene disorders.

PGS with CGH info sheet
PGD Translocation info sheet
PGD Thal info sheet
PGD – Sickle Cell Anaemia